3.4.1 calc should build a .dbd file without any reference to sequencer-dependent code when SNCSEQ is not found in configure/RELEASE, but it wasn't. To fix, edit calcApp/src/Makefile, replacing this: calcSupport.dbd: $(dbdlist) ../editSseq.dbd $(PERL) -MExtUtils::Command -e cat $^ > $@ calc.dbd: $(dbdlist) ../editSseq.dbd $(PERL) -MExtUtils::Command -e cat $^ > $@ with this: calcSupport.dbd: $(dbdlist) $(PERL) -MExtUtils::Command -e cat $^ > $@ calc.dbd: $(dbdlist) $(PERL) -MExtUtils::Command -e cat $^ > $@